As far as area, city houses have a much higher ROI (return on investment) than suburban houses for various reasons . Initial cost is lower and so are taxes. Demand for good rentals is also higher in the city-some landlords only rent to students like at Uof R or RIT and they have a never ending crop of them. It is best to choose one area and buy several in that same area so you can service them more easily-that is what I have done.
Like any investment property price/value is the first consideration, but if you are looking in Irondequoit you
should check to see if it is East or West b/c there is a big difference between the 2 school districts. West Irondequoit will be much more desirable to a family w/school age children.