Other factors not yet mentioned include: are you asking for any seller paid closing costs, how long is your Due Diligence period, how much earnest money and/or due diligence fee will accompany the $150k offer, etc.
The amount of negotiated points on an offer is surprising. Let me know how the offer turned out if you have already made it!
Amanda W. Hallock, awhallock.hpwagents.com
As for making low offers in general, you have to be careful. In today's market, you never know when another offer is going to come in once you get into a haggling war with the seller. Don't be afraid to start low, but make sure it's realistic.
Have your Realtor do a Comparative Market Analysis (CMA) on the property using comps that have SOLD within the last 3-6 months that are within a 1 mile radius of the property (the closer, the better). This will give you current market value and this is what you should base your offer on - not on list price.
You can make any offer you elect to but the lower the offer the greater the chance of being denied. Very low offers may not be responded to by the seller. Your offer should be one that is high enough that it engages the seller and one that you can defend with comparison information.
Without knowing this home or the local market where it is located any attempt to provide you with meaningful information is pure guess work......
A local real estate professional would be able to guide you through this and put you on the path of being able to obtain a home.