It should not be problamatic at all. Any qualified, licensed general contractor should be able to give you some great ideas of other uses for the space. Do your homework on the general contractor that you use... make sure they are licensed, check references, ask for examples of previous work, check with the licensing agency to see if any complaints against the contractor have been filed, etc. All this homework on the front-end will ensure you a successful project and improvements that you can enjoy for a long time.
I had buyers that replaced the Tub with an upgraded Shower!