Sometimes we have clients that are just bound and determined to offer the lowball deal, and so we offer it as they dictate, they end up losing the house because they insulted the seller, and then they listen the next time.
There are alot of buyers out there that want to write alot of offers and see what sticks, if that's their agenda and your comfortable working with them, then you'll just have to identify properties that are more likely to have "lowball offers" entertained more agressively. Some agents prefer to work with more traditional buyers who write offers based upon comps, others are willing to spin the wheel, it all depends on your own business plan/model & time involvement.
If your the listing agent, run the same comps on the buyers agent, ask to see what they base their offer on to flesh out the motivations of the buyer & situation. I counsel my sellers that there are buyers that love to attempt to write "lowball" offers. If all your getting is "lowball" offers, perhaps they're seeing something in the property that everyone on the selling side is overlooking.
Hope that helps,