If you want to stay in Philadelphia, here are my suggestions for you:
Southwest and South Philadelphia will give you very easy access to 95, 76 and the Bridge. It would also be a relatively easy commute to King of Prussia.
Most areas of Northeast Phila. also easily acces 95 and 76, however, it is a longer ride to the Walt Whitman Bridge and to King of Prussia.
Roxborough/Manayunk and East Falls are very far from 95. You could access it by taking 476 S, and then getting onto 95. Your commute to King of Prussia would be decent, but this would be on the lower end of my suggestions for you. Good luck.
If you want to check out home values for a specific place, visit http://www.carolworks4you.com and you can get a market report sent directly to you.
Carol Murray Cei
Mercury Real Estate Group