The area around Santa Row is just fine. If you are buying in the Row itself or close around it.
You will have an excellent ROI.
Let me know if you are looking to buy. Go to my web site http://www.ruthandperry.com
Realtors can not steer clients to or from neighborhoods. You will be able to determine most about a neighborhood if you follow the above suggestion.
Something to consider is that the being closer to retail adds to convenience of shopping, and commuting.