If you are thinking of buying property directly on Ponce De Leon Avenue, then the best section would be along West Ponce De Leon, past Eastlake and West of Adair in Decatur. Look for property set back from the street, don't buy near a major intersection or next to a railroad.
Some of the Druid Hills area townhomes set back from Ponce are pretty nice, East of Briarcliff.
Otherwise, between Briarcliff and Spring Street, you are making a lifestyle choice, not a real estate investment.
Stumbling distance to the Clermont Lounge and the Drunken Unicorn is a cool lifestyle choice...
Keller Williams Realty First Atlanta