If you're more specific with your question, we'll be able to give you more specific answers.
The simple answer to you question is yes you can. Although a 650 score is not great, it's not considered bad either. there are plenty of loans available for folks just like you with what is considered "ok" credit. Much of the terms of your loan will also be determined by other factors such as work history, past tax returns, income and bank statements/account balances. My suggestion would be to talk with a lender before looking at properties so you can find out just what amount you can actually qualify for and what the payments will be. This way you are not looking at homes that are above or below your range and comfort level.
650 is okay, not great but not terrible. Depending on the rest of your application you should be approved for a loan, but others with higher scores will get better terms.
If your score is 740 or higher you qualify for the best rates and terms. If your middle score is 660 or higher it improves, 680 is the next benchmark and 700 and 720 after that. Each 20 point jump improves your pricing for a conventional loan.
If you want to improve your score it may be possible. Talk to a local lender and discuss your entire application and credit report. Best of luck.