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Your handle indicated that you may be living in Harlem, yes? You can always go into the neighborhood at various time of the day to check local activity, restaurants, parks, etc. This will give you a "feel" for the area and give you a fix on the closest subway for your work commute. Good luck.
Fifth Avenue has some great shops in the upper 120's, and of course you have all the shops on 125th. Madison Avenue has some wonderful 19th Century architecture, Astor Row at 130th is entirely preserved with Landmark status, and you have a nice park from 130th-132nd Sts.
If you are taking the trains you have the 2/3 at 135th next to Harlem Hospital, or you can walk over the Madison Ave Bridge to catch the 4/5 trains.
Actually the most important safety concern for you is to be careful of the traffic - that is a very treacherous intersection at 135th and Madison.